Parkinson’s Disease and Dementia: A Longitudinal Study (DEMPARK)
| Autor: | Richard Dodel, Christine Schneider, Annika Spottke, Thomas Gasser, Brit Mollenhauer, Daniela Berg, Hans-Ulrich Wittchen, Carola Seifried, Oliver Riedel, Susanne Gräber-Sultan, Sandra Röske, Günther Deuschl, Alexander Storch, Ullrich Wüllner, Ana Sofia Costa, Jörg B. Schulz, Nele Schmidt, Elke Kalbe, Claudia Trenkwalder, Inga Liepelt-Scarfone, Maren Bodden, Wolfgang H. Oertel, Monika Balzer-Geldsetzer, Karsten Witt, Martin Kronenbürger, Thomas Klockgether, Rüdiger Hilker |
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| Rok vydání: | 2011 |
| Předmět: |
complications [Lewy Body Disease]
Male Motor disorder Pediatrics Longitudinal study Parkinson's disease Epidemiology Disease Neuropsychological Tests Cohort Studies 0302 clinical medicine genetics [Lewy Body Disease] genetics [Parkinson Disease] blood [Parkinson Disease] Prospective Studies 030212 general & internal medicine 10. No inequality Prospective cohort study complications [Dementia] ddc:616 Aged 80 and over medicine.diagnostic_test Parkinson Disease Middle Aged Magnetic Resonance Imaging 3. Good health Parkinson Demenz Kohortenstudie Disease Progression Female complications [Parkinson Disease] complications [Cognitive Dysfunction] Parkinson’s disease Dementia MCI cognitive impairment Cohort study Lewy Body Disease Mild Cognitive Impairment medicine.medical_specialty 03 medical and health sciences genetics [Dementia] medicine Humans Parkinson's disease dementia MCI cognitive impairment cohort study Cognitive Dysfunction ddc:610 Aged blood [Lewy Body Disease] business.industry genetics [Cognitive Dysfunction] Magnetic resonance imaging medicine.disease blood [Dementia] blood [Cognitive Dysfunction] Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neuroepidemiology, 2011, Bd. 37, Nr. 3-4, S. 168–176, ISSN: 0251-5350 Neuroepidemiology 37(3-4), 168-176 (2011). doi:10.1159/000331490 |
| ISSN: | 1423-0208 0251-5350 |
| DOI: | 10.1159/000331490 |
| Popis: | Background: Parkinson’s disease (PD) is a progressive neurodegenerative motor disorder. However, non-motor complications frequently alter the course of the disease. A particularly disabling non-motor symptom is dementia. Methods/Design: The study is designed as a multicentre prospective, observational cohort study of about 700 PD patients aged 45–80 years with or without dementia and PD-mild cognitive impairment (MCI). The patients will be recruited in eight specialized movement disorder clinics and will be followed for 36 months. Information about the patients’ functional status will be assessed at baseline and 6-/12- month intervals. In addition, 120 patients with dementia with Lewy bodies (DLB) will be included. Well-established standardized questionnaires/tests will be applied for detailed neuropsychological assessment. In addition, patients will be asked to participate in modules including volumetric MRI, genetic parameters, and neuropsychology to detect risk factors, early diagnostic biomarkers and predictors for dementia in PD. Results: The study included 604 PD patients by March 2011; 56.3% were classified as having PD alone, with 30.6% of patients suffering from PD-MCI and 13.1% from PD with dementia. The mean age of the cohort was 68.6 ± 7.9 years, with a mean disease duration of 6.8 ± 5.4 years. There was a preponderance of patients in the earlier Hoehn and Yahr stages. Conclusion: The main aim of the study is to characterize the natural progression of cognitive impairment in PD and to identify factors which contribute to the evolution and/or progression of the cognitive impairment. To accomplish this aim we established a large cohort of PD patients without cognitive dysfunction, PD patients with MCI, and PD patients with dementia, to characterize these patients in a standardized manner, using imaging (serial structural MRI), genetic and proteomic methods in order to improve our understanding of the course of the PD process and the development of cognitive dysfunction and dementia in this disease. The inclusion of the DLB patients will start in the second quarter of 2011 in the BMBF-funded follow-up project LANDSCAPE. |
| Databáze: | OpenAIRE |
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