Transcriptome analysis and co‐expression network reveal the mechanism linking mitochondrial function to immune regulation in red crucian carp ( Carassius auratus red var) after Aeromonas hydrophila challenge

Autor:	Ning‐Xia Xiong, Xu‐Ying Kuang, Zi‐Xuan Fang, Jie Ou, Shi‐Yun Li, Jia‐Hui Zhao, Jin‐Fang Huang, Ke‐Xin Li, Rou Wang, Lan‐Fen Fan, Sheng‐Wei Luo, Shao‐Jun Liu
Rok vydání:	2022
Předmět:	Fish Proteins Carps Gene Expression Profiling Veterinary (miscellaneous) Aquatic Science Kidney Neoplasms Aeromonas hydrophila Mitochondria Fish Diseases Goldfish Animals Gram-Negative Bacterial Infections Transcriptome Carcinoma Renal Cell
Zdroj:	Journal of Fish Diseases. 45:1491-1509
ISSN:	1365-2761 0140-7775
DOI:	10.1111/jfd.13677
Popis:	Aeromonas hydrophila is a common pathogen of freshwater fish. In this study, A. hydrophila infection was shown to cause tissue damage, trigger physiological changes as well as alter the expression profiles of immune- and metabolic-related genes in immune tissues of red crucian carp (RCC). Transcriptome analysis revealed that acute A. hydrophila infection exerted a profound effect on mitochondrial oxidative phosphorylation linking metabolic regulation to immune response. In addition, we further identified cellular senescence, apoptosis, necrosis and mitogen-activated protein kinase signal pathways as crucial signal pathways in the kidney of RCC subjected to A. hydrophila infection. These findings may have important implications for understanding modulation of immunometabolic response to bacterial infection.
Databáze:	OpenAIRE
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