Long-term follow-up of a vaccination program for infants born to HBsAg-positive mothers in Stockholm County, Sweden

Autor: Jenny Stenkvist, Gudrun Lindh, Agneta Samuelson, Mona Insulander, Björn Fischler
Rok vydání: 2020
Předmět:
Male
HBsAg
Pediatrics
medicine.medical_specialty
Time Factors
Long term follow up
030231 tropical medicine
Immunization
Secondary
Booster dose
medicine.disease_cause
Serology
03 medical and health sciences
Hepatitis B
Chronic
0302 clinical medicine
Pregnancy
medicine
Humans
Hepatitis B Vaccines
Longitudinal Studies
030212 general & internal medicine
Hepatitis B Antibodies
Pregnancy Complications
Infectious
Seroconversion
Child
Sweden
Hepatitis B virus
Hepatitis B Surface Antigens
General Veterinary
General Immunology and Microbiology
Immunization Programs
business.industry
Vaccination
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
virus diseases
Infectious Disease Transmission
Vertical
digestive system diseases
Chronic infection
Infectious Diseases
Molecular Medicine
Female
business
Follow-Up Studies
Zdroj: Vaccine. 38:790-793
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2019.10.100
Popis: We investigated the long-term antibody response to hepatitis B virus (HBV) vaccination in babies born to chronically infected mothers. They received one dose of monovalent HBV vaccination at birth and one month of age, followed by 3 doses of hexavalent vaccine including an HBV component at ages 3, 5, and 12 months, respectively, with a very high percentage of protective anti-HBs levels at 13 months. At the age of 8–12 years, 56 out of 68 children (82%) had protective levels of anti-HBs, two had signs of anti-HBc seroconversion without any history of clinical disease and none had ongoing infection. A small subgroup was retested after one booster dose, in all resulting in increase in anti-HBs from below 10 IU/L to levels corresponding to protective immunity. We conclude that this vaccination strategy is effective throughout the first decade of life in avoiding chronic infection and in maintaining a good serological response.
Databáze: OpenAIRE
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