Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and immature stages of the cat flea (Ctenocephalides felis) on cats
| Autor: | Joseph B. Prullage, Rosentel Joseph K, David R. Young, Martin Knaus, S. Theodore Chester, William R. Everett, Steffen Rehbein, Josephus J. Fourie, Christine F. Baker, Eric Tielemans |
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| Rok vydání: | 2014 |
| Předmět: |
Veterinary medicine
Flea Efficacy Cat flea Eggs medicine.disease_cause Cat Diseases Praziquantel chemistry.chemical_compound Random Allocation Flea Infestations (S)-methoprene Infestation parasitic diseases medicine Animals Fipronil Ctenocephalides Life Cycle Stages Eprinomectin CATS Ivermectin General Veterinary biology Antiparasitic Agents Felis General Medicine biology.organism_classification Methoprene veterinary(all) Ctenocephalides felis Drug Combinations Treatment Outcome chemistry Fleas Topical Cats Pyrazoles Parasitology medicine.drug |
| Zdroj: | Veterinary Parasitology. 202(1-2):54-58 |
| ISSN: | 0304-4017 |
| DOI: | 10.1016/j.vetpar.2014.02.040 |
| Popis: | The efficacy of a novel topical combination of fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v) and praziquantel 8.3% (w/v) (BROADLINE(®)) was tested against adult and immature stages of Ctenocephalides felis fleas in six studies. For that purpose, fleas from different colonies from North America, Germany and South Africa were used to induce infestations in cats under laboratory conditions. In each study, between 12 and 16 cats were allocated randomly to 2 groups. Cats in Group 1 were not treated and served as controls. Cats in Group 2 were treated once on Day 0 with BROADLINE(®) at the minimum recommended dosage of 0.12 mg/kg body weight. In 4 studies, all animals were infested experimentally with unfed C. felis (100 ± 5) on Days 2 (or 1), 7, 14, 21, 28 and 35. Live fleas were counted 24h post-treatment or infestation. In 2 additional studies, animals were infested at the same frequency with gravid C. felis fleas (100 ± 5) that were fed previously on an untreated host. Forty-eight hours post-infestation, flea eggs were collected, counted and incubated for the evaluation of the reduction of emergence of adults. The combined curative efficacy against adult fleas at 24h after treatment was 94.3% and the combined preventive efficacy values remained greater than 95.9% at 24h after 5 subsequent weekly infestations. In addition, the product reduced dramatically the emergence of new adult fleas for at least 5 weeks (>98.1% for one month and 93.2% at 5 weeks after infestation), demonstrating its efficiency in preventing environmental contamination by immature stages. |
| Databáze: | OpenAIRE |
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