Brain metastases of mouse mammary adenocarcinoma is increased by acute stress
| Autor: | Stanley Jocobson, Jacek Rożniecki, Kai Tao, Duraisamy Kempuraj, G. Gary Sahagian, Bodi Zhang, Theoharis C. Theoharides |
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| Rok vydání: | 2010 |
| Předmět: |
Diagnostic Imaging
Restraint Physical Pathology medicine.medical_specialty Corticotropin-Releasing Hormone Ratón Central nervous system Breast Neoplasms Adenocarcinoma Blood–brain barrier Metastasis Mice Corticotropin-releasing hormone Cell Line Tumor Animals Medicine Molecular Biology Blood-Testis Barrier Photons Brain Neoplasms business.industry General Neuroscience Brain Mammary Neoplasms Experimental Cancer medicine.disease Mast cell Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Female Neurology (clinical) business Developmental Biology |
| Zdroj: | Brain Research. 1366:204-210 |
| ISSN: | 0006-8993 |
| Popis: | Brain metastases from mammary adenocarcinoma constitute the chief cause of morbidity and mortality. Some evidence suggests that stress may contribute to disease progression and metastases. Here we show that acute restraint stress (30 min) induces statistically significant increase in brain metastases of systemically administered luciferase-tagged 4T1-BR-3P mouse mammary adenocarcinoma cells as evidenced by the total brain-associated photons from 5.6 × 10(7) photons in unstressed controls to 1.7 × 10(8) photons in C57BL/6 (p = 0.0018) and from 7.6 × 10(7) to 2.1 × 10(7) photons in BALB/c (p = 0.004) mice. Acute stress may increase metastases by disrupting the blood-brain-barrier (BBB), through release of corticotropin-releasing-hormone (CRH) activating perivascular brain mast cells. |
| Databáze: | OpenAIRE |
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