Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Autor:	Linda Broer, Dirk Goossens, Ben A. Oostra, Cornelia M. van Duijn, A. Dessa Sadovnick, Eva Greiner, Jurgen Del-Favero, Sreeram V. Ramagopalan, Wangko Lundström, Jan Hillert, George C. Ebers, Naghmeh Jafari, I A Hoppenbrouwers, Yurii S. Aulchenko, Jenny Link, Rogier Q. Hintzen, Christine Van Broeckhoven
Přispěvatelé:	Epidemiology, Neurology, Clinical Genetics
Rok vydání:	2008
Předmět:	Genetics Multiple sclerosis Axonal loss Locus (genetics) Odds ratio Biology medicine.disease Gene expression Genetic variation medicine Genetic variability Human medicine Gene
Zdroj:	Nature genetics Nature Genetics, 40(12), 1402-1403. Nature Publishing Group
ISSN:	1061-4036
Popis:	Rogier Hintzen and colleagues report the results of a search for genetic variants associated with susceptibility to multiple sclerosis in a genetically isolated population that lead to identification of a new susceptibility locus in the region of the KIF1B gene on chromosome 1. The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 × 10−10). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3704342651d048a6c64a5d6af220637f https://hdl.handle.net/1765/30208 Zobrazit plný text záznamu Plný text ve formátu PDF