Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
Autor: | Linda Broer, Dirk Goossens, Ben A. Oostra, Cornelia M. van Duijn, A. Dessa Sadovnick, Eva Greiner, Jurgen Del-Favero, Sreeram V. Ramagopalan, Wangko Lundström, Jan Hillert, George C. Ebers, Naghmeh Jafari, I A Hoppenbrouwers, Yurii S. Aulchenko, Jenny Link, Rogier Q. Hintzen, Christine Van Broeckhoven |
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Přispěvatelé: | Epidemiology, Neurology, Clinical Genetics |
Rok vydání: | 2008 |
Předmět: | |
Zdroj: | Nature genetics Nature Genetics, 40(12), 1402-1403. Nature Publishing Group |
ISSN: | 1061-4036 |
Popis: | Rogier Hintzen and colleagues report the results of a search for genetic variants associated with susceptibility to multiple sclerosis in a genetically isolated population that lead to identification of a new susceptibility locus in the region of the KIF1B gene on chromosome 1. The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 × 10−10). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term. |
Databáze: | OpenAIRE |
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