Effects of intensive urate lowering therapy with febuxostat in comparison with allopurinol on pulse wave velocity in patients with gout and increased cardiovascular risk
| Autor: | Martijn Gerritsen, Marek Rajzer, Giovambattista Desideri, Cristina Giannattasio, Anne-Kathrin Tausche, Claudio Borghi, Michael T. Nurmohamed |
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| Přispěvatelé: | Rheumatology, ACS - Atherosclerosis & ischemic syndromes, AII - Inflammatory diseases, Desideri, G, Rajzer, M, Gerritsen, M, Nurmohamed, M, Giannattasio, C, Tausche, A, Borghi, C |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
musculoskeletal diseases
Adult medicine.medical_specialty Gout pulse wave velocity Allopurinol Urology hyperuricemia 030204 cardiovascular system & hematology Pulse Wave Analysis Gout Suppressants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Febuxostat Risk Factors medicine Humans Pharmacology (medical) 030212 general & internal medicine Hyperuricemia Adverse effect Pulse wave velocity business.industry nutritional and metabolic diseases medicine.disease Uric Acid Thiazoles Treatment Outcome chemistry Cardiovascular Diseases Heart Disease Risk Factors Arterial stiffness Uric acid allopurinol febuxostat gout xanthine oxidase Cardiology and Cardiovascular Medicine business Hyperuricaemia medicine.drug |
| Zdroj: | European Heart Journal-Cardiovascular Pharmacotherapy, 8(3), 236-242. Oxford University Press Desideri, G, Rajzer, M, Gerritsen, M, Nurmohamed, M T, Giannattasio, C, Tausche, A-K & Borghi, C 2022, ' Effects of intensive urate lowering therapy with febuxostat in comparison with allopurinol on pulse wave velocity in patients with gout and increased cardiovascular risk : the FORWARD study ', European heart journal. Cardiovascular pharmacotherapy, vol. 8, no. 3, pp. 236-242 . https://doi.org/10.1093/ehjcvp/pvaa144 European heart journal. Cardiovascular pharmacotherapy, 8(3), 236-242. Oxford University Press |
| ISSN: | 2055-6837 |
| Popis: | Aims Hyperuricaemia and gout are strongly related with traditional cardiovascular risk factors and vascular damage. This study aimed to assess whether febuxostat and allopurinol could differently influence carotid-femoral pulse wave velocity (cfPWV) in patients with gout and elevated serum uric acid (SUA) levels. Methods and results A multi-centre, multinational, phase IV, randomized, parallel-group, active-controlled, open-label trial with blind endpoints evaluation. One hundred and ninety-seven adults with gout and SUA levels ≥8 mg/dL were randomized to febuxostat or allopurinol in a 1:1 ratio for 36 weeks. The primary outcome was the comparison of the effects of febuxostat and allopurinol on changes in cfPWV. The mean cfPWV values at randomization and Week 36 were 8.69 and 9.00 m/s, respectively for subjects randomized to febuxostat and 9.02 and 9.05 m/s for subjects randomized to allopurinol. No statistically significant changes in cfPWV by treatment assignment were observed at any time point for any of the assessed parameters. More subjects who received febuxostat had serum urate concentrations ≤6 mg/dL following treatment (78.3% vs. 61.1% at Week 36, P = 0.0137). Treatment-emergent adverse events were reported by 51 (52.0%) patients randomized to febuxostat and 63 (62.5%) patients randomized to allopurinol. The majority of events were mild in both treatment groups and included gout flares and arthralgia. Conclusion In patients with gout and elevated SUA levels the arterial stiffness remained stable both with febuxostat and allopurinol. Febuxostat was more effective and faster than allopurinol in achieving the SUA target. Both treatments were safe and well tolerated. |
| Databáze: | OpenAIRE |
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