Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis
Autor: | Torben A Kruse, Mads Thomassen, Jan Baumbach, Zsolt Illes, Tobias Frisch, Tim Kacprowski, Richard Reynolds, Mark Burton, Maria L. Elkjaer |
---|---|
Rok vydání: | 2019 |
Předmět: |
Immunoglobulin gene
Pathology medicine.medical_specialty Context (language use) Biology lcsh:RC346-429 Pathology and Forensic Medicine Multiple sclerosis Lesion White matter 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Gene expression medicine Humans TGF-beta lcsh:Neurology. Diseases of the nervous system 030304 developmental biology 0303 health sciences Microglia Sequence Analysis RNA Research Gene Expression Profiling Receptor Transforming Growth Factor-beta Type II Brain High-Throughput Nucleotide Sequencing Multiple Sclerosis Chronic Progressive medicine.disease White Matter ddc 3. Good health CD26/DPP4 Next-generation RNA sequencing medicine.anatomical_structure Human brain lesions Immunohistochemistry Secondary progressive Neurology (clinical) medicine.symptom 030217 neurology & neurosurgery |
Zdroj: | Acta Neuropathologica Communications Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-17 (2019) Elkjaer, M L, Frisch, T, Reynolds, R, Kacprowski, T, Burton, M, Kruse, T A, Thomassen, M, Baumbach, J & Illes, Z 2019, ' Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis ', Acta Neuropathologica Communications, vol. 7, 205 . https://doi.org/10.1186/s40478-019-0855-7 |
ISSN: | 2051-5960 |
Popis: | To identify pathogenetic markers and potential drivers of different lesion types in the white matter (WM) of patients with progressive multiple sclerosis (PMS), we sequenced RNA from 73 different WM areas. Compared to 25 WM controls, 6713 out of 18,609 genes were significantly differentially expressed in MS tissues (FDR n = 2213), remyelinating lesions had the highest gene expression levels, and the most different molecular map from chronic active lesions. This may suggest that these two lesion types represent two ends of the spectrum of lesion evolution in PMS. The profound changes in chronic active lesions, the predominance of synaptic/neural/axonal signatures coupled with minor inflammation may indicate end-stage irreversible molecular events responsible for this less treatable phase. |
Databáze: | OpenAIRE |
Externí odkaz: |