Outcome and renal function following salvage surgery for bilateral Wilms tumor: a single-institution experience
| Autor: | Karl Sampath, Reju Joseph Thomas, Tarun John K Jacob, Aureen D'Cunha, Jujju Jacob Kurian, Susan Jehangir, John Mathai, Rebekah Grace |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Chemotherapy bilateral Wilms creatinine clearance hypertension nephron sparing surgery business.industry Medical record medicine.medical_treatment 030232 urology & nephrology Renal function Abdominal mass Surgery 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health medicine Salvage surgery Nephron sparing surgery medicine.symptom business Postoperative Hypertension Bilateral Wilms Tumor |
| Zdroj: | Annals of Pediatric Surgery; Vol 13, No 3 (2017); 145-149 |
| ISSN: | 1687-4137 |
| Popis: | Objective: The aim of this study was to determine the surgical outcomes and renal function following salvage surgery for bilateral Wilms tumor (BWT). Summary background data The challenge for the surgeon treating BWT lies in striking a fine balance between renal preservation and oncological clearance. Methods: This is a retrospective review of medical records in a tertiary care hospital in India. Nine children with BWT who presented between 2005 and 2015 were reviewed and followed up through telephone. Survival rates were calculated using the Kaplan–Meier method. A P value of less than 0.05 was considered statistically significant. Results: Seven (78%) of nine children were boys and two (22%) were syndromic. Six (67%) children presented at less than 1 year of age. Eight (89%) children presented with an abdominal mass. There were no metastases at presentation. All children underwent trucut biopsy and neoadjuvant chemotherapy. Six children underwent surgery: four underwent bilateral nephron sparing surgery (NSS) and two underwent unilateral nephrectomy with contralateral NSS. Tumor recurred in two children. The mean follow-up was 38 months (range: 5–108 months). Creatinine clearance (CrCl) improved postoperatively in all children. Postoperative hypertension was transient and resolved with improvement in CrCl. Conclusion: Children with BWT in the Indian subcontinent may be younger than those in the rest of the world. NSS yields good outcomes even for recurrences. Postoperative hypertension is transient in the majority of patients and correlated with improvement in CrCl. Prognosis is related to operability and syndromic association. Keywords: bilateral Wilms, creatinine clearance, hypertension, nephron sparing surgery |
| Databáze: | OpenAIRE |
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