Novel carbazole and acyl-indole antimitotics
| Autor: | Barta Thomas E, Amy F. Barabasz, James Marvin Veal, Geng Lifeng, John W. Rice, Steven E. Hall, Hanson Gunnar J, Wei Ma, Briana Foley, Matthew Jenks |
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| Rok vydání: | 2009 |
| Předmět: |
Indoles
Ketone medicine.drug_class Stereochemistry Clinical Biochemistry Carbazoles Pharmaceutical Science Carboxamide Antimitotic Agents Biochemistry Chemical synthesis chemistry.chemical_compound Tubulin Cell Line Tumor Drug Discovery medicine Humans Colchicine HSP90 Heat-Shock Proteins Molecular Biology chemistry.chemical_classification Indole test Bicyclic molecule biology Chemistry Carbazole Organic Chemistry biology.protein Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 19:3078-3080 |
| ISSN: | 0960-894X |
| Popis: | In the course of our Heat Shock 90 program, certain carbazole compounds were identified which had an off-target antiproliferative activity. To understand the off-target activity, we studied one analog with strong activity. We discovered that it had an effect on tubulin polymerization kinetics and was competitive with colchicine. Additional analogs were made, and a number of potent compounds were identified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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