Role of regenerative therapies on erectile dysfunction after radical prostatectomy
| Autor: | S. T. Hansen, Lars Lund, M. Lund, L. D. Ostergaard |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male medicine.medical_specialty Urology medicine.medical_treatment 030232 urology & nephrology MEDLINE 03 medical and health sciences 0302 clinical medicine Primary outcome Erectile Dysfunction Prostate Internal medicine medicine Animals Humans Prostatectomy 030219 obstetrics & reproductive medicine business.industry Penile Erection Prostatectomy/adverse effects Stem-cell therapy medicine.disease medicine.anatomical_structure Erectile dysfunction Animal studies Erectile Dysfunction/etiology Stem cell business Penis |
| Zdroj: | Hansen, S T, Lund, M, Ostergaard, L D & Lund, L 2021, ' Role of regenerative therapies on erectile dysfunction after radical prostatectomy ', International Journal of Impotence Research, vol. 33, no. 4, pp. 488-496 . https://doi.org/10.1038/s41443-020-00406-3 |
| ISSN: | 1476-5489 |
| DOI: | 10.1038/s41443-020-00406-3 |
| Popis: | The present study provides a review of stem cell therapy as a treatment of erectile dysfunction from peer-reviewed human and animal trials. A literature search was conducted in PubMed-Medline, Scopus, Embase, and Cochrane databases. Tweenty-three animal studies and seven human studies in the period from 1st of January 2000 to 1st of Mai 2020 were included. The seven included human studies are primary phase one trials, and most of them treat erectile dysfunction following radical prostatectomy by injection of stem cells into the corpus cavernosum. The primary outcome measure in all human trials is safety and secondary can stem cells play a role in the recovery of erectile function. All studies conclude that it is safe to use stem cells and the majority of the studies demonstrate an improvement in erectile function. The results from both animal and human trials are promising for stem cells as a restorative treatment, but data from large randomized human phase two trials is missing before it can be concluded, that stem cells is an effective treatment for erectile dysfunction in humans. |
| Databáze: | OpenAIRE |
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