[Laryngotracheal NK/T lymphoma: clinical case]
| Autor: | Falening Melissa de la Rosa Astacio, Rafael Barberá Durbán, Ignacio Cobeta Marco, Miguel Vaca González |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty In situ hybridization Flow cytometry Neoplasms Multiple Primary Young Adult Immunophenotyping Fatal Outcome Biopsy medicine Humans Laryngeal Neoplasms medicine.diagnostic_test biology business.industry General Medicine medicine.disease Lethal midline granuloma Lymphoma Lymphoma Extranodal NK-T-Cell Perforin biology.protein Immunohistochemistry Female Tracheal Neoplasms business |
| Zdroj: | Acta otorrinolaringologica espanola. 62(1) |
| ISSN: | 1988-3013 |
| Popis: | NK/T-cell lymphoma is a rare condition with an aggressive course and poor prognosis. Historically known as «lethal midline granuloma», it generally appears in a midfacial location. We describe the case of a 22-year-old Colombian woman with laryngotracheal affectation, presenting with hoarseness and hemoptysis. CT scan and MRI showed severe laryngeal and tracheal destruction. The biopsy showed a polymorphic, lymphoid cell infiltrate with angiocentric and angiodestructive pattern. The immunohistochemical study confirmed the immunophenotype of the NK/T-cells: CD2+, CD56+ and cytoplasmic CD3+. The in situ hybridization and flow cytometry findings were: EBER+, TIA-1+ and perforin+. The patient died from complications of her disease, before undergoing oncologic treatment. |
| Databáze: | OpenAIRE |
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