Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study
| Autor: | Paul Maruff, Alan G. Harris, Pia Burman, John A.H. Wass, Marina G. Falleti, Mahesh Sathiavageeswaran, David Lawrence |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Single Center Placebo Placebo group Cognition Endocrinology Double-Blind Method Memory Internal medicine medicine Humans Insulin-Like Growth Factor I Young adult Adverse effect Aged Dose-Response Relationship Drug Human Growth Hormone business.industry General Medicine Middle Aged Recombinant Proteins Affect Female Age of onset business GH Deficiency |
| Zdroj: | European Journal of Endocrinology. 156:439-447 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.1.02346 |
| Popis: | Objective: Young adults with childhood-onset GH deficiency (GHD) have reduced memory and attention, which can be improved by treatment with GH. Little information is available on cognitive function in elderly GHD patients. Design: Single center, double-blind, randomized, placebo-controlled study of 52-week duration. Methods: Elderly GH therapy naïve GHD patients (n=34; age range 60–77 years) were enrolled and randomized to receive placebo or GH therapy which was titrated to achieve a target IGF-I level of +1 to +2 s.d. of the normal mean for age. Cognitive function was assessed at baseline and after 24 and 52 weeks, using a computerized psychometric test package (Neurobehavioral Examination System-2). Results: The mean GH dose was 0.16±0.06 mg/day; mean IGF-I increased from 135±59 ng/ml at baseline to 213±77 ng/ml during active treatment. The GH-treated group had better mean serial digit learning scores compared with placebo group (P Conclusion: This study indicates that GH replacement may be accompanied by improvement in certain measures of cognitive function in elderly patients with GHD. |
| Databáze: | OpenAIRE |
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