Sterepinic Acids A–C, New Carboxylic Acids Produced by a Marine Alga-Derived Fungus
| Autor: | Takashi Kikuchi, Miwa Matsuda, Megumi Hirose, Mayuko Seki, Takeshi Yamada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereum sp Spectrophotometry Infrared Stereochemistry Carboxylic Acids Pharmaceutical Science Undaria pinnatifida Marine Biology Fungus Spectrometry Mass Fast Atom Bombardment phenylglycine methyl ester method 010402 general chemistry 01 natural sciences Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Lactones lcsh:Organic chemistry Cell Line Tumor Drug Discovery Humans Marine alga Physical and Theoretical Chemistry Cytotoxicity marine microorganism biology 010405 organic chemistry sterepinic acids Organic Chemistry Absolute configuration Fungi biology.organism_classification Seaweed 0104 chemical sciences NMR spectra database chemistry Chemistry (miscellaneous) Molecular Medicine vibralactones Derivative (chemistry) |
| Zdroj: | Molecules Volume 23 Issue 6 Molecules, Vol 23, Iss 6, p 1336 (2018) Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules23061336 |
| Popis: | Sterepinic acids A&ndash C (1&ndash 3), new carboxylic acids with two primary alcohols, have been isolated from a fungal strain of Stereum sp. OUPS-124D-1 attached to the marine alga Undaria pinnatifida. Dihydro-1,5-secovibralactone (4), a new vibralactone derivative, was isolated from the same fungal metabolites together with known vibralactone A (5), and 1,5-secovibralactone (6). The planar structures of these compounds have been elucidated by spectroscopic analyses using IR, HRFABMS, and NMR spectra. To determine the absolute configuration of the compounds, we used the phenylglycine methyl ester (PGME) method. These compounds exhibited less activity in the cytotoxicity assay against cancer cell lines. |
| Databáze: | OpenAIRE |
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