Peripapillary and macular choroidal thickness before and after phenylephrine instillation
| Autor: | Soraya Fonseca, Alfonso Casado, Miguel A Gordo-Vega, Alicia López-de-Eguileta, Jorge Gaitán |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Retinal Ganglion Cells Mydriatics medicine.medical_specialty Future studies genetic structures Optic Disk Administration Ophthalmic Article Phenylephrine 03 medical and health sciences chemistry.chemical_compound Nerve Fibers 0302 clinical medicine Ophthalmology Healthy control medicine Humans Macula Lutea Cycloplegic agent Aged Aged 80 and over Choroid business.industry Pupil Mean age Retinal Middle Aged Healthy Volunteers eye diseases chemistry 030221 ophthalmology & optometry Female sense organs Enhanced depth imaging Ophthalmic Solutions business Tomography Optical Coherence 030217 neurology & neurosurgery Ct measurements medicine.drug |
| Zdroj: | Eye (Lond) |
| ISSN: | 1476-5454 0950-222X |
| DOI: | 10.1038/s41433-019-0478-z |
| Popis: | OBJECTIVES: We investigated the effects of topical phenylephrine 2.5% instillation on choroidal thickness (CT), peripapillary choroidal thickness (pCT) and retinal nerve fibre layer (RNFL). METHODS: Healthy control patients underwent enhanced depth imaging (EDI) by spectral-domain optical coherence tomography (OCT) before and 30 min after phenylephrine instillation, using eye-tracking and follow-up software. Changes in 14 different locations of CT, 2 locations of pCT and RNFL were assessed. RESULTS: The study included 119 eyes of 62 patients (19 males and 43 females), with a mean age of 59.8 ± 15.3 years (range: 26-88 years). Within 30 min after instillation, the mean subfoveal CT both in vertical and horizontal scan were significantly thinned (p = 0.005 and p = 0.018, respectively). In total, 1500, 1000 and 500 µm temporal CT measurements showed also a significant thinning (p = 0.021, p = 0.037 and p = 0.020, respectively), as well as 500 µm both superior (p = 0.045) and inferior (p = 0.009). 1500, 1000 and 500 µm nasal CT, and 1500 and 1000 µm CT superior and inferior measurements showed no significant thinning after phenylephrine instillation. pCT was significantly thinned after phenylephrine in both superior (p = 0.016) and inferior (p = 0.050) measurements. RNFL analysis did not significantly change after phenylephrine instillation (p = 0.209). CONCLUSIONS: A significant thinning of CT and pCT occurred following phenylephrine instillation. Future studies analysing CT and pCT should detail if this mydriatic agent was used or not. |
| Databáze: | OpenAIRE |
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