Carbetocin versus syntometrine for prevention of postpartum hemorrhage after cesarean section
| Autor: | Noura El-Nassery, Walaa Ai Mostafa, Amal Kotb, Ahmed M. Maged, Sherif Dahab, Ahmed Shaker Ragab |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Hemodynamics Hematocrit Postoperative Hemorrhage Oxytocin law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial Double-Blind Method law Pregnancy Oxytocics medicine Humans Ergometrine 030212 general & internal medicine Ergonovine 030219 obstetrics & reproductive medicine medicine.diagnostic_test Obstetrics business.industry Cesarean Section Postpartum Hemorrhage Infant Newborn Obstetrics and Gynecology Puerperal Disorders medicine.disease Tolerability Pediatrics Perinatology and Child Health Carbetocin Female business medicine.drug |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 30(8) |
| ISSN: | 1476-4954 |
| Popis: | To compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of postpartum hemorrhage (PPH) after cesarean section (CS).A double-blind randomized study conducted on 300 pregnant subjected randomly either to single 100 μg IV dose of carbetocin (150 women) or combination of 5 IU oxytocin and 0.2 mg ergometrine (150 women) after fetal extraction and before placental removal. Primary outcome parameter was the occurrence of PPH. Other parameters were hemoglobin and hematocrit changes, the need of additional oxytocic, hemodynamic changes and occurrence of side effects.There was no significant difference between the two study groups regarding hemoglobin and hematocrit at start of CS and after 2 days of surgery and mean blood loss during the operation (p 0.05). There was a highly significant difference between the two study groups regarding incidence of primary PPH (2.7% versus10%) and the need of additional oxytocic (3.3% versus17.3%). Women in oxytocin group showed a statistically significant lower systolic and diastolic blood pressure at 1, 5 and 30 min than women in carbetocin group. Women in carbetocin group experienced more metallic taste, flushing, headache, dizziness, dyspnea and itching, while women in oxytocin methergine group experienced more palpitations.Carbetocin is a reasonable effective alternative to syntometrine in prevention of PPH after cesarean delivery. |
| Databáze: | OpenAIRE |
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