Protective Effect of 940 nm Laser on Gamma-Irradiated Mice
| Autor: | Zuzana Sinkorova, Leoš Navrátil, Yulia Efremova |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Longevity
Biomedical Engineering Biology law.invention Blood cell Mice Random Allocation law medicine Animals Radiology Nuclear Medicine and imaging Irradiation Low-Level Light Therapy Mitosis Original Research Lethal dose Gamma ray Laser Molecular biology Blood Cell Count Mice Inbred C57BL Haematopoiesis medicine.anatomical_structure Gamma Rays Immunology Female Lasers Semiconductor Gamma irradiation |
| Zdroj: | Photomedicine and Laser Surgery. 33:82-91 |
| ISSN: | 1557-8550 1549-5418 |
| Popis: | Objective: The purpose of this study was to investigate the radioprotective features of 940 nm laser on the life span of mice, and absolute counts of blood cells and their proportions in gamma-irradiated mice. Background data: An important feature of laser light is activation of mitotic division and differentiation of cells, which may be useful in activation of hematopoiesis in gamma-irradiated organisms. Materials and methods: Mice were randomly assigned to 11 groups according to the type(s) of influence. Generally, mice were irradiated in three different ways: with laser at different fluences, with gamma irradiation, or by combination of laser at different fluences and gamma irradiation in a different order. Mice were treated with 940 nm laser at 3, 12, or 18 J/cm2 and/or a lethal dose of gamma irradiation (8.7 Gy). Each group was randomly subdivided into two subgroups, in which the life span of the mice and blood cell counts (on 12th and 45th day after gamma irradiation) were analyzed. Results: Laser (940 nm) at a fluence of 3 J/cm2 significantly prolonged the life span of gamma-irradiated mice (p |
| Databáze: | OpenAIRE |
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