Saliva cortisol, melatonin levels and circadian rhythm alterations in Chinese primary school children with dyslexia
| Autor: | Wenlong Huang, Meirong He, Kusheng Wu, Chongtao Xu, Yanhong Huang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
circadian rhythm China endocrine system medicine.medical_specialty Saliva Hydrocortisone Observational Study melatonin cortisol Chronobiology Disorders Dyslexia Melatonin 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans risk factors 030212 general & internal medicine Circadian rhythm Child Salivary cortisol Morning business.industry Case-control study General Medicine medicine.disease Endocrinology Case-Control Studies 030220 oncology & carcinogenesis Normal children Female business hormones hormone substitutes and hormone antagonists Research Article medicine.drug |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Cortisol is the main end product of hypothalamic-pituitary-adrenal gland (HPA axis), and melatonin (MT) has a regulating effect on HPA axis, and both are closely related to individual behavior and cognitive function. We aimed to evaluate cortisol and MT roles on children dyslexia in this study. A total of 72 dyslexic children and 72 controls were recruited in this study. Saliva samples were collected in the morning, afternoon, and night, respectively. The levels of saliva cortisol and MT were measured by enzyme-linked immunosorbent assay method. Differences of cortisol and MT levels between dyslexic and normal children were compared, and the variation trend was also analyzed by dynamic monitoring in 3 time points. The levels of salivary cortisol and MT in children with dyslexia were all lower than those in normal children whether in the morning (7:30-8:30 am ), at afternoon (15:30-16:30 pm ) or at night (21:30-22:30 pm ) (all P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|