Selective Elimination of HIV-1-Infected Cells with an Interleukin-2 Receptor-Specific Cytotoxin
| Autor: | Robert W. Finberg, Gopalan Soman, Jean C. Nichols, Sharon M. Wahl, J B Allen, John R. Murphy, Terry B. Strom |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Interleukin 2
Cell Survival Recombinant Fusion Proteins T-Lymphocytes medicine.medical_treatment HIV Core Protein p24 Gene Products gag HIV Infections In Vitro Techniques Biology medicine.disease_cause Virus HIV Envelope Protein gp160 Microbiology Cell surface receptor Fusion Toxin medicine Humans Diphtheria Toxin Protein Precursors Receptor Diphtheria toxin Multidisciplinary Toxin Viral Core Proteins Gene Products env Receptors Interleukin-2 Virology Cytokine HIV-1 Interleukin-2 medicine.drug |
| Zdroj: | Science. 252:1703-1705 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1904628 |
| Popis: | Infection by human immunodeficiency virus type 1 (HIV-1) is associated with cellular activation and expression of the interleukin-2 (IL-2) receptor. A genetically engineered fusion toxin, DAB486 IL-2, that contains the enzymatic site and translocation domain of diphtheria toxin and the receptor binding domain of IL-2 specifically kills cells that express high-affinity IL-2 receptors. This toxin selectively eliminated the HIV-1-infected cells from mixed cultures of infected and uninfected cells and inhibited production of viral proteins and infectious virus. Thus, cellular activation antigens present a target for early antiviral intervention. |
| Databáze: | OpenAIRE |
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