Influence of quinidine and propranolol on the intracellular distribution of 45Ca in rat heart
| Autor: | Donald J. Baxter, Loyal L. Conrad |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Quinidine
medicine.medical_specialty chemistry.chemical_element Propranolol Pharmacology Calcium Biology Cell Fractionation General Biochemistry Genetics and Molecular Biology Cell membrane Internal medicine Microsomes medicine Distribution (pharmacology) Animals Cell Nucleus Myocardium Cell Membrane Mitochondria Muscle Rats medicine.anatomical_structure Endocrinology chemistry Microsome Female Cell fractionation Intracellular medicine.drug |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 150(2) |
| ISSN: | 0037-9727 |
| Popis: | The intracellular distribution of 45Ca in the rat heart was studied following separate and combined administration of quinidine and propranolol. Both drugs caused an increased uptake of 45Ca in the nuclear-cell membrane fraction but quinidine suppressed the uptake in mitochondrial and microsomal fractions whereas propranolol did not affect the uptake of 45Ca in these fractions. In addition, there was an increase in serum radioactivity noted with quinidine which was not observed with propranolol. Combined treatment resulted in restoration of normal values for blood and mitochondrial fractions and an increased uptake of 45Ca in the microsomal fraction. |
| Databáze: | OpenAIRE |
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