Plasma Atrial Natriuretic Peptide (ANP) Concentration in Patients with Pheochromocytoma
| Autor: | Feltynowski T, Stepniakowski K, Lapiński M, Andrzej Januszewicz, Jolanta Chodakowska, Ignatowska-Switalska H, Włodzimierz Januszewicz, Wocial B |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Adrenal Gland Neoplasms Endogeny Pheochromocytoma Essential hypertension Catecholamines Atrial natriuretic peptide Internal medicine Surgical removal Healthy volunteers Internal Medicine medicine Humans In patient Aged business.industry General Medicine Middle Aged medicine.disease Endocrinology Female Cardiology and Cardiovascular Medicine business Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Blood Pressure. 1:157-161 |
| ISSN: | 1651-1999 0803-7051 |
| Popis: | The interaction between catecholamines (CA) and ANP is not clearly established. The effects of excess endogenous CA on ANP secretion can be investigated in patients with pheochromocytoma. We studied 27 patients with surgically and histologically proven pheochromocytoma (P) aged 19-70 years. In 16 of these patients plasma ANP study was repeated after surgical removal of the tumour. The control group (C) consisted of 20 healthy volunteers aged 21-48 years. Moreover, 42 patients with uncomplicated mild to moderate essential hypertension (EH) aged 18-48 years were also studied. In P higher plasma ANP concentration versus C, EH was found (51.9 +/- 8.1; 25.5 +/- 1.5; 19.3 +/- 1.5 fmol/ml, respectively). In 16 patients with P, increased plasma ANP level (mean 63.3 +/- 12.6 fmol/ml) declined after surgical removal of the tumour (mean 22.4 +/- 2.9 fmol/ml). In the P patients no relationship was found between plasma ANP and hormonal patterns of the tumour or between plasma ANP and plasma catecholamines, whereas significant positive correlations between plasma ANP and both systolic and diastolic blood pressure and heart rate were demonstrated. These results suggest that excess CA produced by the chromaffin tumour induce ANP secretion via stimulation of adrenergic receptors. However, influence of the haemodynamic changes evoked by CA cannot be excluded. It is suggested that increased secretion of ANP may be of some importance in maintaining blood pressure homeostasis in patients with pheochromocytoma. |
| Databáze: | OpenAIRE |
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