Stabilizing synthetic DNA for long-term data storage with earth alkaline salts
| Autor: | Karin Strauss, Robert N. Grass, Bichlien H. Nguyen, Weida D. Chen, Philipp L. Antkowiak, Wendelin J. Stark, A. Xavier Kohll, Luis Ceze |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Calcium Phosphates
Surface Properties Magnesium Chloride chemistry.chemical_element Salt (chemistry) Information Storage and Retrieval 02 engineering and technology Calcium Catalysis 03 medical and health sciences chemistry.chemical_compound Calcium Chloride Materials Chemistry A-DNA Particle Size 030304 developmental biology chemistry.chemical_classification 0303 health sciences Magnesium Metals and Alloys General Chemistry DNA 021001 nanoscience & nanotechnology Accelerated aging Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Long term data Ceramics and Composites Salts 0210 nano-technology Earth (classical element) Nuclear chemistry |
| Zdroj: | Chemical Communications, 56 (25) |
| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.3929/ethz-b-000408365 |
| Popis: | Rapid aging tests (70 °C, 50% RH) of solid state DNA dried in the presence of various salt formulations, showed the strong stabilizing effect of calcium phosphate, calcium chloride and magnesium chloride, even at high DNA loadings (>20 wt%). A DNA-based digital information storage system utilizing the stabilizing effect of MgCl2 was tested by storing a DNA file, encoding 115 kB of digital data, and the successful readout of the file by sequencing after accelerated aging. Chemical Communications, 56 (25) ISSN:1359-7345 ISSN:1364-548X |
| Databáze: | OpenAIRE |
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