Administration of hydro-alcoholic extract of spinach improves oxidative stress and inflammation in high-fat diet-induced NAFLD rats
| Autor: | Hadi Emamat, Ali Amirinejad, Farzad Shidfar, Majid Safa, Azita Hekmatdoost, Ali Saneei Totmaj, Farzaneh Mardali |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Inflammation Diet High-Fat medicine.disease_cause Rats Sprague-Dawley Superoxide dismutase Liver disease Other systems of medicine Non-alcoholic Fatty Liver Disease Spinacia oleracea Weight loss Internal medicine NAFLD Nonalcoholic fatty liver disease medicine Animals biology Plant Extracts Tumor Necrosis Factor-alpha business.industry Research NASH Spinach biology.organism_classification medicine.disease Enzyme assay Rats Disease Models Animal Endocrinology Liver Complementary and alternative medicine Oxidative stress biology.protein medicine.symptom business RZ201-999 |
| Zdroj: | BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-10 (2021) BMC Complementary Medicine and Therapies |
| ISSN: | 2662-7671 |
| Popis: | Background Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The aim of this study was to evaluate the effects of hydro-alcoholic extract of spinach (HES) on hepatic and serum measurements of NAFLD in a rat model. Methods In the prevention phase, 18 Sprague–Dawley rats were fed a high-fat diet, a high-fat diet plus 400 mg/kg HES, or a chow diet for seven weeks. For the treatment phase, after the induction of NAFLD, they were fed a high-fat diet, a high-fat diet plus 400 mg/kg HES, a chow diet, or a chow diet plus 400 mg/kg HES for four weeks (n = 6). Results Administration of HES combined with high-fat diet in rats was associated with decreased food intake (P P = 0.01), and increased superoxide dismutase (SOD) (P = 0.02) enzyme activity in the liver, at the end of the prevention phase. hs-CRP (P P P P P = 0.03) and hepatic GPX (P = 0.01) enzyme activity. Conclusion Taking into account the potential beneficial effects of HES on prevention and treatment of NAFLD in the present study, to confirm these findings, we propose that further clinical trials be conducted on human subjects with NAFLD. |
| Databáze: | OpenAIRE |
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