Preoperative N-terminal pro-B-type natriuretic peptide for prediction of acute kidney injury after non-cardiac surgery: A retrospective cohort study
| Autor: | Shao-Hui Lei, Bing-Cheng Zhao, Cai Li, Xiao Yang, Wei-Feng Liu, Pei-Pei Zhuang, Shi-Da Qiu, Ke-Xuan Liu |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
China medicine.medical_specialty medicine.drug_class Serum Creatinine Measurement Risk Assessment Cohort Studies 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors 030202 anesthesiology Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Prospective Studies Prospective cohort study Retrospective Studies business.industry Acute kidney injury 030208 emergency & critical care medicine Retrospective cohort study Acute Kidney Injury Prognosis medicine.disease Peptide Fragments Clinical trial Anesthesiology and Pain Medicine Cohort business Biomarkers Kidney disease |
| DOI: | 10.21203/rs.2.23625/v2 |
| Popis: | BACKGROUND Acute kidney injury (AKI) is associated with poor outcomes after noncardiac surgery. Whether pre-operative N-terminal pro-B-type natriuretic peptide (NT-proBNP) predicts AKI after noncardiac surgery is unclear. OBJECTIVE To investigate the predictive role of pre-operative NT-proBNP on postoperative AKI. DESIGN Retrospective cohort study. SETTING Nanfang Hospital, Southern Medical University, China. PATIENTS Adult patients who had a serum creatinine and NT-proBNP measurement within 30 pre-operative days and at least one serum creatinine measurement within 7 days after noncardiac surgery between February 2008 and May 2018 were identified. MAIN OUTCOME MEASURES The primary outcome was postoperative AKI, defined by the kidney disease: improving global outcomes creatinine criteria. RESULTS In all, 6.1% (444 of 7248) of patients developed AKI within 1 week after surgery. Pre-operative NT-proBNP was an independent predictor of AKI after adjustment for clinical variables (OR comparing top to bottom quintiles 2.29, 95% CI, 1.47 to 3.65, P |
| Databáze: | OpenAIRE |
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