Secretory component of immunoglobulin A in maternal serum and the prediction of preterm delivery
| Autor: | Rennae S. Taylor, Jean-Claude Schellenberg, Ren Li Zhou, Robyn A. North |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Immunoglobulin A medicine.medical_specialty Adolescent Secretory component Population Physiology Enzyme-Linked Immunosorbent Assay Obstetric Labor Premature Pregnancy Internal medicine Humans Medicine Longitudinal Studies Prospective Studies Prospective cohort study education education.field_of_study biology business.industry Smoking Pregnancy Outcome Obstetrics and Gynecology Gestational age medicine.disease Endocrinology ROC Curve Case-Control Studies Immunoglobulin A Secretory Nested case-control study biology.protein Gestation Female business Infant Premature |
| Zdroj: | American Journal of Obstetrics and Gynecology. 178:535-539 |
| ISSN: | 0002-9378 |
| Popis: | OBJECTIVE: Our purpose was to determine whether the secretory component of immunoglobulin A in maternal serum predicts delivery before 34 weeks' gestation. STUDY DESIGN: Primigravid women of an urban population in New Zealand were recruited at booking into a prospective longitudinal nested case control study ( n = 1651; after exclusions and withdrawals, n = 1511). Serum was collected at 8 to 12 weeks, 15 to 18 weeks, 21 to 24 weeks, 28 to 30 weeks, and 36 to 38 weeks of gestation and 6 weeks post partum. Concentrations of the secretory component of immunoglobulin A were determined by enzyme-linked immunosorbent assay in all women who were delivered preterm ( n = 53) and in controls randomly selected from women delivered at ≥37 weeks' gestation ( n = 178). RESULTS: Serum concentrations of the secretory component of immunoglobulin A were similar in women delivered at term or preterm throughout pregnancy ( n = 21 delivered at n = 32 at 34 to 36.9 weeks, incidence 3.5%). Receiver-operator characteristic curves showed no discriminating ability of the secretory component of immunoglobulin A. Smokers had 50% higher concentrations than nonsmokers did ( p CONCLUSION: The secretory component of immunoglobulin A in maternal serum does not predict preterm delivery in a low-risk population. (Am J Obstet Gynecol 1998;178:535-9.) |
| Databáze: | OpenAIRE |
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