Absence of food effects on the pharmacokinetics of terfenadine
| Autor: | Mark G. Eller, Kelly K. Antony, Bruce E. Mcnutt, Barbara J. Walker, Richard A. Okerholm, Lianng Yuh |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Metabolite Pharmaceutical Science Biological Availability Histamine H1 receptor Absorption (skin) Pharmacology chemistry.chemical_compound Pharmacokinetics Internal medicine medicine Humans Pharmacology (medical) Terfenadine Active metabolite Gastric emptying Chemistry General Medicine Metabolism Fasting Dietary Fats Endocrinology Intestinal Absorption medicine.drug |
| Zdroj: | Biopharmaceuticsdrug disposition. 13(3) |
| ISSN: | 0142-2782 |
| Popis: | Administration of terfenadine (Seldane) immediately after a high fat breakfast slightly affects the rate but not the extent of absorption relative to fasting administration. Mean peak levels of the active metabolite were increased by 13 per cent but delayed by 0.9 h while AUC was virtually the same as when terfenadine was administered while fasting. Changes in rate of absorption may be due to delayed gastric emptying and more rapid terfenadine solubilization. In any case, these rate differences are unlikely to be clinically important in the absence of differences in extent of absorption. |
| Databáze: | OpenAIRE |
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