The catecholamine neurotransmitter precursor tyrosine increases anger during exposure to severe psychological stress
| Autor: | Harris R. Lieberman, James P. McClung, Lauren A. Thompson, Gregory R. Caron, Philip J. Niro, Christina M. Caruso, Caroline R. Mahoney |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Dopamine Anger Cortisol Interrogation chemistry.chemical_compound Norepinephrine Young Adult Double-Blind Method Heart Rate Internal medicine Military Heart rate Mood medicine Humans Tyrosine Neurotransmitter Saliva Original Investigation chemistry.chemical_classification Pharmacology Chemistry Amino acid Affect Endocrinology SERE Catecholamine Female Stress Psychological medicine.drug |
| Zdroj: | Psychopharmacology |
| ISSN: | 1432-2072 |
| Popis: | Rationale Acute stress produces behavioral and physiological changes modulated by central catecholamines (CA). Stress increases CA activity, and depletion of CA stores reduces responses to stress. Increasing CA activity by administration of the dietary amino acid CA precursor tyrosine may increase responsiveness to stress. This study determined whether tyrosine enhances the ability of humans to respond to severe stress. Methods Severe psychological stress was generated during training at Survival, Evasion, Resistance, and Escape (SERE) School. The acute stressor consisted of two mock interrogations conducted during several days of simulated captivity. Seventy-eight healthy male and female military personnel participated in this double-blind, between-subjects study, in which they received either tyrosine (300 mg/kg, N = 36) or placebo (N = 36). Tyrosine (or placebo) was administered in food bars in two doses of 150 mg/kg each approximately 60 min before each mock interrogation. Mood (Profile of Mood States), saliva cortisol, and heart rate (HR) were assessed prior to stress exposure during a week of academic training preceding mock captivity and immediately following the mock interrogations. Results The severe stress produced robust effects on mood (i.e., increased tension, depression, anger, fatigue, vigor, and confusion; p |
| Databáze: | OpenAIRE |
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