Phosphorylated Lamins in Euchromatin: New Clues to Progeria
| Autor: | Bas van Steensel, Stefano G. Manzo |
|---|---|
| Přispěvatelé: | Cell biology |
| Rok vydání: | 2020 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities 0303 health sciences Progeria animal structures integumentary system Euchromatin Cell Biology Biology medicine.disease General Biochemistry Genetics and Molecular Biology Cell biology 03 medical and health sciences 0302 clinical medicine Transcription (biology) embryonic structures medicine Nuclear lamina Phosphorylation Molecular Biology 030217 neurology & neurosurgery Lamin 030304 developmental biology Developmental Biology |
| Zdroj: | Developmental Cell Developmental Cell, 52, 676-678. Cell Press |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2020.03.003 |
| Popis: | Lamin proteins not only form the nuclear lamina, but some are also found in the nuclear interior. In this issue of Developmental Cell, Ikegami et al. describe that phosphorylated Lamin C in the nuclear interior interacts with enhancer-like elements and link this to deregulated transcription in progeria. |
| Databáze: | OpenAIRE |
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