Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study
| Autor: | Jérôme Massardier, Valérie Goua, Aline Receveur, Pascale Kleinfinger, Isabelle Monier, Véronique Houfflin-Debarge, Florent Fuchs, Anne-Hélène Saliou, Guillaume Benoist, Marion Groussolles, Anne-Sylvie Valat, Alexandra Benachi, Sophie Degre, Jennifer Zeitlin, Vanina Castaigne, Jean-Marie Jouannic, Hanane Bouchghoul, Vassilis Tsatsaris, Eve Mousty, Thierry Rousseau |
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| Přispěvatelé: | Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Saclay, Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Intercommunal de Créteil (CHIC), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Morvan - CHRU de Brest (CHU - BREST ), Hôpital Bicêtre, CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CH Lens, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CH Le Havre, Hospices Civils de Lyon (HCL), Hôpital Cochin [AP-HP], Université Paris Descartes - Paris 5 (UPD5), Laboratoire CERBA [Saint Ouen l'Aumône], Fuchs, Florent |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Prenatal diagnosis [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics Andrology fetal growth restriction 03 medical and health sciences 0302 clinical medicine chromosomal microarray Pregnancy medicine Humans 030212 general & internal medicine Copy-number variation Retrospective Studies Fetus Fetal Growth Retardation 030219 obstetrics & reproductive medicine prenatal diagnosis Microarray analysis techniques business.industry Obstetrics and Gynecology Karyotype General Medicine Microarray Analysis medicine.disease Confidence interval karyotype [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics embryonic structures Female France Trisomy business copy number variants |
| Zdroj: | American Journal of Obstetrics and Gynecology American Journal of Obstetrics and Gynecology, 2021, 225 (6), pp.676.e1-676.e15. ⟨10.1016/j.ajog.2021.05.035⟩ |
| ISSN: | 0002-9378 |
| Popis: | International audience; Background: Compared with standard karyotype, chromosomal microarray analysis improves the detection of genetic anomalies and is thus recommended in many prenatal indications. However, evidence is still lacking on the clinical utility of chromosomal microarray analysis in cases of isolated fetal growth restriction.Objective: This study aimed to estimate the proportion of copy number variants detected by chromosomal microarray analysis and the incremental yield of chromosomal microarray analysis compared with karyotype in the detection of genetic abnormalities in fetuses with isolated fetal growth restriction.Study design: This retrospective study included all singleton fetuses diagnosed with fetal growth restriction and no structural ultrasound anomalies and referred to 13 French fetal medicine centers over 1 year in 2016. Fetal growth restriction was defined as an estimated fetal weight of |
| Databáze: | OpenAIRE |
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