Effects of milrinone on blood flow of the Y-graft composed with the radial and the internal thoracic artery in patients with coronary artery disease
| Autor: | Sungwon Na, Seo Ouk Bang, Young Jun Oh, Young Lan Kwak, Yong Woo Hong, Yon Hee Shim |
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| Rok vydání: | 2006 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Cardiotonic Agents Phosphodiesterase Inhibitors Vasodilator Agents Hemodynamics Internal thoracic artery Coronary Artery Disease Coronary artery disease Internal medicine medicine.artery Coronary Circulation medicine Humans Radial artery Mammary Arteries Internal Mammary-Coronary Artery Anastomosis Aged Intraoperative Care business.industry General Medicine Blood flow Middle Aged medicine.disease surgical procedures operative medicine.anatomical_structure Anesthesia Circulatory system Radial Artery Cardiology Milrinone Surgery Female Vascular Resistance Cardiology and Cardiovascular Medicine business medicine.drug Artery |
| Zdroj: | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 30(2) |
| ISSN: | 1010-7940 |
| Popis: | OBJECTIVE Milrinone has been known to dilate the internal thoracic artery (ITA) and the radial artery (RA). The effect of milrinone, however, on each graft is unclear when the left ITA (LITA) and the RA form a Y-graft. This study evaluated the changes in blood flow of a composite Y-graft in response to milrinone. METHODS Thirty-two patients undergoing an isolated coronary artery bypass graft surgery were included in this study. A Y-graft was created with an in situ LITA and free RA graft attached to the proximal side of the LITA. Graft flow was measured by opening the graft end for 30s, and is expressed in 'ml/min'. Graft flow and hemodynamic data were recorded before and 10 min after intravenous milrinone (50 microg/kg) administration. RESULTS Milrinone significantly increased the RA graft flow, measured while the LITA graft end was clamped, and total Y-graft flow. Respective graft flows were not increased by milrinone when both clamps were released simultaneously, in spite of a significant decrease in the resistance of both grafts. The ratio of flows through the RA and the LITA grafts was not changed by milrinone. CONCLUSION Milrinone significantly reduced RA and LITA resistances and increased the total Y-graft flow. Milrinone might dilate each individual arterial graft to a different degree. Milrinone did not, however, change the flow ratio through the RA to LITA grafts when they were measured simultaneously. Therefore, it would not significantly divert graft flow to one side in a composite Y-graft. |
| Databáze: | OpenAIRE |
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