Activity-Dependent Neurotrophic Factor Peptide (ADNF9) Protects Neurons Against Oxidative Stress-Induced Death
| Autor: | Mark P. Mattson, Gordon W. Glazner, Illana Gozes, Albert Dresse, Douglas E. Brenneman, André Boland |
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| Rok vydání: | 2002 |
| Předmět: |
Programmed cell death
medicine.medical_specialty Amyloid Molecular Sequence Data Apoptosis Nerve Tissue Proteins Peptide Biology medicine.disease_cause Hippocampus Biochemistry Culture Media Serum-Free Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Neurotrophic factors Internal medicine medicine Animals Amino Acid Sequence Ferrous Compounds Cells Cultured Cerebral Cortex Neurons chemistry.chemical_classification Reactive oxygen species Peptide Fragments Mitochondria Rats Cell biology Oxidative Stress Endocrinology chemistry Tetrodotoxin Reactive Oxygen Species Oxidative stress |
| Zdroj: | Journal of Neurochemistry. 73:2341-2347 |
| ISSN: | 0022-3042 |
| DOI: | 10.1046/j.1471-4159.1999.0732341.x |
| Popis: | Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-d-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species. |
| Databáze: | OpenAIRE |
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