Diagnostic and Therapeutic Values of Angiogenic Factors in Endometrial Cancer
| Autor: | Luka Roškar, Irena Roškar, Tea Lanišnik Rižner, Špela Smrkolj |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
udc:616-006
Neovascularization Pathologic angiogenic factors biomarkers Review Biochemistry Microbiology rak endometrija QR1-502 Endometrial Neoplasms Neoplasm Proteins anti-angiogenic therapy angiogenesis endometrial cancer Humans angiogeneza Angiogenesis Inducing Agents Female Molecular Targeted Therapy Molecular Biology biomarkerji |
| Zdroj: | Biomolecules, Vol 12, Iss 7, p 7 (2022) Biomolecules Biomolecules, vol. 12, no. 1, 7, 2022. |
| ISSN: | 2218-273X |
| Popis: | Endometrial cancer (EC) is the most frequent gynecological malignancy in developed countries and requires a relatively invasive diagnostic evaluation and operative therapy as the primary therapeutic approach. Angiogenesis is one of the main processes needed for cancer growth and spread. The production of angiogenic factors (AFs) appears early in the process of carcinogenesis. The detection of AFs in plasma and tissue and a better understanding of the angiogenic properties of EC may contribute not only to earlier but also more specific diagnosis and consequently tailored and individual therapeutic approaches. AFs and their receptors also have high potential as binding sites for targeted cancer therapy. In this review, we discuss angiogenesis in EC and the characteristics of the AFs that most contribute to angiogenesis in EC. We also highlight therapeutic strategies that target angiogenesis as potential EC therapy. |
| Databáze: | OpenAIRE |
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