Effects of an Allostatic Closed-Loop Neurotechnology (HIRREM) on Brain Functional Connectivity Laterality in Military-Related Traumatic Stress
| Autor: | Dale Dagenbach, Sung W. Lee, Catherine L. Tegeler, Ashley R. Morgan, Sean L. Simpson, Paul J. Laurienti, Lee Gerdes, Charles H. Tegeler |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Rest Lateralization of brain function Functional Laterality Article 030218 nuclear medicine & medical imaging Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Neurotechnology Intervention (counseling) Medicine Humans Radiology Nuclear Medicine and imaging Veterans Functional MRI medicine.diagnostic_test Resting state fMRI business.industry Traumatic stress Brain Magnetic resonance imaging network connectivity Middle Aged posttraumatic stress Magnetic Resonance Imaging HIRREM medicine.anatomical_structure Military Personnel laterality Laterality Neurology (clinical) business 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Journal of neuroimaging : official journal of the American Society of Neuroimaging |
| ISSN: | 1552-6569 |
| Popis: | Background and purpose Brain asymmetries are reported in posttraumatic stress disorder, but many aspects of laterality and traumatic stress remain underexplored. This study explores lateralization changes in resting state brain network functional connectivity in a cohort with symptoms of military-related traumatic stress, associated with use of a closed-loop neurotechnology, HIRREM. Methods Eighteen participants (17 males, mean age 41 years [SD = 7]) received 19.5 (1.1) HIRREM sessions over 12 days. Whole brain resting magnetic resonance imaging was done pre- and post-HIRREM. Laterality of functional connectivity was assessed on a whole brain basis, and in six predefined networks or regions. Laterality of connectivity within networks or regions was assessed separately from laterality of connections between networks or regions. Results Before HIRREM, significant laterality effects of connection type (ipsilateral for either side, or contralateral in either direction) were observed for the whole brain, within networks or regions, and between networks or regions. Post-HIRREM, there were significant changes for within-network or within-region analysis in the motor network, and changes for between-network or between-region analyses for the salience network and the motor cortex. Conclusions Among military service members and Veterans with symptoms of traumatic stress, asymmetries of network and brain region connectivity patterns were identified prior to usage of HIRREM. A variety of changes in lateralized patterns of brain connectivity were identified postintervention. These laterality findings may inform future studies of brain connectivity in traumatic stress disorders, with potential to point to mechanisms of action for successful intervention. |
| Databáze: | OpenAIRE |
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