Revisiting the mouse model of oxygen-induced retinopathy
| Autor: | Patricia A. D'Amore, Kip M. Connor, Clifford Kim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Angiogenesis Review Bioinformatics Oxygen induced retinopathy angiogenesis 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine 030304 developmental biology 0303 health sciences Retina business.industry Retinopathy of prematurity Retinal Diabetic retinopathy OIR Macular degeneration medicine.disease ROP eye diseases Sensory Systems 3. Good health medicine.anatomical_structure chemistry 030221 ophthalmology & optometry sense organs business Retinopathy |
| Zdroj: | Eye and Brain |
| ISSN: | 1179-2744 |
| Popis: | Abnormal blood vessel growth in the retina is a hallmark of many retinal diseases, such as retinopathy of prematurity (ROP), proliferative diabetic retinopathy, and the wet form of age-related macular degeneration. In particular, ROP has been an important health concern for physicians since the advent of routine supplemental oxygen therapy for premature neonates more than 70 years ago. Since then, researchers have explored several animal models to better understand ROP and retinal vascular development. Of these models, the mouse model of oxygen-induced retinopathy (OIR) has become the most widely used, and has played a pivotal role in our understanding of retinal angiogenesis and ocular immunology, as well as in the development of groundbreaking therapeutics such as anti-vascular endothelial growth factor injections for wet age-related macular degeneration. Numerous refinements to the model have been made since its inception in the 1950s, and technological advancements have expanded the use of the model across multiple scientific fields. In this review, we explore the historical developments that have led to the mouse OIR model utilized today, essential concepts of OIR, limitations of the model, and a representative selection of key findings from OIR, with particular emphasis on current research progress. |
| Databáze: | OpenAIRE |
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