Tubular structures in the cervix of mice experimentally infected with herpes simplex virus type 2
| Autor: | Ryoichi Mori, Tsuyoshi Iwasaka, Hiroshi Oda, Yuwao Hino |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
viruses
Cervix Uteri Biology Virus Replication medicine.disease_cause Virus law.invention Uterine Cervical Diseases Mice law Virology medicine Animals Simplexvirus Cervix Vaginitis Inoculation medicine.disease Disease Models Animal Microscopy Electron Titer Infectious Diseases medicine.anatomical_structure Herpes simplex virus Genital tract Vagina Female Electron microscope |
| Zdroj: | Journal of Medical Virology. 5:117-122 |
| ISSN: | 1096-9071 0146-6615 |
| DOI: | 10.1002/jmv.1890050204 |
| Popis: | Experimental infection of the C3H/N mouse genital tract was demonstrated after intravaginal inoculation with herpes simplex virus type 2 (HSV-2). About 75% of the infected animals died by Day 7, and 75% of the surviving animals had severe vaginitis or neurological signs on Day 7. Titers of the virus recovered from vaginal secretions of infected animals reached a maximum on Day 2 and gradually decreased until Day 7. On the other hand, under the electron microscope, virus particles and tubular structures could be found in the nuclei of infected cells of the cervix in the 1st, 2nd and 4th days after infection. All cases in which virus particles could be found in the nuclei of infected cells were also positive for tubular structures and vice versa. These observations indicate that in situ diagnosis of HSV-2 infection can be made in the mouse model. The same method would be applicable for the diagnosis of human HSV-2 infection. |
| Databáze: | OpenAIRE |
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