The effect of mono(2-ethylhexyl) phthalate on Sertoli cell transferrin secretion in vitro
| Autor: | Michael Gatz, Patricia L. Morris, Benjamin Thysen, Eric Bloch |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Biology Testicle Toxicology Follicle-stimulating hormone chemistry.chemical_compound In vivo Diethylhexyl Phthalate Internal medicine medicine Animals Secretion Cells Cultured Pharmacology chemistry.chemical_classification Sertoli Cells Transferrin Phthalate Rats Inbred Strains Sertoli cell Rats Endocrinology medicine.anatomical_structure chemistry Toxicity Follicle Stimulating Hormone |
| Zdroj: | Toxicology and Applied Pharmacology. 106:154-157 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(90)90115-b |
| Popis: | We have examined the effect of mono(2-ethylhexyl) phthalate (MEHP) on the secretion of rat transferrin (rTf) by Sertoli cells (SC) in the presence and absence of FSH. Significant decreases in rTf secretion were observed in SC cultures exposed to 50 and 75 microM MEHP, in the absence of FSH. Treatment of SC with FSH (300 ng/ml) obviated this suppression of rTf secretion by MEHP. These findings indicate an effect of MEHP on rTf secretion by SC in vitro which could account for the testicular toxicity of MEHP in vivo. |
| Databáze: | OpenAIRE |
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