Effects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma
| Autor: | Serdar Tarhan, H Deveci, Cihan Göktan, Esin F. Erkin, Cenap Güler, Ozcan Kayikcioglu |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Intraocular pressure genetic structures Open angle glaucoma Retinal Artery Glaucoma Betaxolol Ciliary Arteries 03 medical and health sciences chemistry.chemical_compound Tonometry Ocular 0302 clinical medicine medicine.artery medicine Humans In patient Prospective Studies Latanoprost Ultrasonography Doppler Color Antihypertensive Agents Intraocular Pressure business.industry General Medicine Blood flow Middle Aged medicine.disease eye diseases Ciliary arteries Ophthalmology chemistry Regional Blood Flow Anesthesia Prostaglandins F Synthetic 030221 ophthalmology & optometry Female sense organs Ophthalmic Solutions Visual Fields business 030217 neurology & neurosurgery Blood Flow Velocity Glaucoma Open-Angle medicine.drug |
| Zdroj: | European journal of ophthalmology. 14(3) |
| ISSN: | 1120-6721 |
| Popis: | Purpose To evaluate the effects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma (POAG) by means of an obseiver-masked, prospective clinical study. METHODS Thirty-two patients with newly diagnosed POAG were included in the study. The patients were randomized into two groups. The first group was treated with betaxolol 0.50% twice daily and the second group with latanoprost 0.005% once daily. Baseline and post-treatment examinations on the first and third months of treatment included intraocular pressure (IOP) measurement, automated visual field testing, and ocular blood flow assessment. For evaluation of visual fields, mean defect and pattern standard deviation indices were used. Ocular blood flow was assessed by means of color Doppler imaging of the central retinal artery (CRA) and the temporal short posterior ciliary artery (PCA). For each vessel, peak systolic (PSV) and end-diastolic (EDV) blood flow velocities were measured and resistivity index (RI) calculated. Results After exclusion of one noncompliant patient, the study was completed with 31 eyes of 31 patients. Both drugs significantly reduced IOP (p0.05). There were no significant changes in PSV or EDV measurements of CRA or PCA in either group (p>0.05). RI decreased in both CRA and PCA with both drugs. The mean changes between baseline and 3 month blood flow measurements were not significantly different between betaxolol and latanoprost (p>0.05). CONCLUSIONS Over a treatment period of 3 months, both betaxolol and latanoprost tended to improve ocular blood flow without one of them being superior to the other. The results suggest that the direct (non IOP-dependent) influence on ocular circulation is better for betaxolol than for latanoprost. In addition, neither drug caused significant generalized improvements in visual fields during this period. |
| Databáze: | OpenAIRE |
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