Lead (Pb) exposure is associated with changes in the expression levels of circulating miRNAS (miR-155, miR-126) in Mexican women
| Autor: | José A. Varela-Silva, Sandra T. Orta-García, Ángeles C. Ochoa-Martínez, Leticia Carrizales-Yáñez, Iván N. Pérez-Maldonado |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Circulating mirnas Health Toxicology and Mutagenesis Pcr assay 010501 environmental sciences Toxicology 01 natural sciences Epigenesis Genetic Andrology miR-155 03 medical and health sciences Downregulation and upregulation microRNA Humans Medicine Epigenetics Inverse correlation Mexico 030304 developmental biology 0105 earth and related environmental sciences Pharmacology 0303 health sciences business.industry Environmental Exposure General Medicine Middle Aged MicroRNAs Lead Positive relationship Environmental Pollutants Female business |
| Zdroj: | Environmental Toxicology and Pharmacology. 83:103598 |
| ISSN: | 1382-6689 |
| DOI: | 10.1016/j.etap.2021.103598 |
| Popis: | The environmental contamination with lead (Pb) is considered a critical issue worldwide. Therefore, this study aimed to evaluate the expression levels of circulating miRNAs (miR-155, miR-126, and miR-145) in Mexican women exposed to Pb. Blood lead levels (BLL) were assessed in enrolled women (n = 190) using an atomic absorption method. Also, serum miRNAs expression levels were quantified through a real-time PCR assay. A mean BLL of 10.5 ± 4.50 μg/dL was detected. Overexpression of miR-155 was detected in highly exposed women. Besides, a significant simple positive relationship (p < 0.05) was found between BLL and serum miR-155 expression levels. Additionally, a significant inverse correlation (p < 0.05) was determined between BLL and serum miR-126 expression levels, as downregulation of miR-126 expression levels was observed in highly exposed women. The findings in this study are the concern, as epigenetic changes detected may represent a connection between health illnesses and Pb exposure. |
| Databáze: | OpenAIRE |
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