Studies on the plasma membrane of normal and psoriatic keratinocytes
| Autor: | van Erp Pe, H. Roelfzema, Mieke Bergers, van de Kerkhof P, P.D. Mier, van den Hurk Jj, J.M. Gommans |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Adolescent Epinephrine medicine.drug_class Stimulation Cell Separation Dermatology Cyclase Basal (phylogenetics) Fluocinolone acetonide Internal medicine Cyclic AMP medicine Animals Humans Psoriasis Skin Chemistry Middle Aged Stimulation Chemical Membrane Endocrinology Fluocinolone Acetonide Hormone receptor Keratins Corticosteroid Cattle Female Histamine Hormone medicine.drug |
| Zdroj: | British Journal of Dermatology. 101:413-419 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1979.tb00019.x |
| Popis: | Cyclic AMP levels have been determined for the first time in isolated keratinocytes. Values were more reproducible than those reported using epidermal slices. Evidence is presented to show that damage to hormone receptors is minimal. Other observations include the following: (1) Keratinocytes from psoriatic lesions showed reduced 'resting' levels of cyclic AMP as well as a diminished response to adrenaline. (2) Cyclic AMP levels were maximal in the basal cells, falling dramatically in fully differentiated keratinocytes. (3) The topical application of a corticosteroid (fluocinolone acetonide) did not modulate the response of adenyl cyclase to hormonal stimulation. |
| Databáze: | OpenAIRE |
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