| Autor: |
Tengteng Yuan, Shujie Lv, Wei Zhang, Yanan Tang, Hong Chang, Zihan Hu, Liang Fang, Jiaojiao Du, Sifan Wu, Xinli Yang, Yangfu Guo, Ruihan Guo, Zongrui Ge, Lei Wang, Caiyun Zhang, Rulin Wang, Weidong Chen |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
International journal of pharmaceutics. 615 |
| ISSN: |
1873-3476 |
| Popis: |
Paeoniflorin (PF) has a certain therapeutic effect on cholestasis liver injury. To further improve the bioavailability of PF and play its pharmacological role in liver protection, PF-phospholipid complex micelles (PF-PLC micelles) were prepared based on our previous research on PF-PLC. The protective effects of PF and PF-PLC micelles on cholestasis liver injury induced by 17α-ethynylestradiol (EE) were compared, and the possible mechanisms were further explored. Herein, we showed that PF-PLC micelles effectively improved liver function, alleviated liver pathological damage, and localized infiltration of inflammatory cells. Mechanism studies indicated that PF-PLC micelles treatment could suppress the TLR4/MyD88/NF-κB pathway, and further reduce the levels of pro-inflammatory factors. Meanwhile, our experimental results demonstrated that the beneficial effect of PF-PLC micelles on EE-induced cholestasis may be achieved by the upregulation of nuclear receptors and metabolic enzymes (PXR/CAR/UGT1A1). All these results indicate that PF-PLC micelles have great potential in the treatment of cholestatic liver disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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