SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice
| Autor: | Derek C. Rogers, Majid Hafezparast, Elizabeth M. C. Fisher, Jo Peters, Sharon J. Nicholson, Tracey L. Robinson, Abi S. Witherden, Judy Latcham, Charlotte A. Quilter, Joanne E. Martin, Simon T. Ball |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Pathology Longitudinal study Genotype Movement Posture Neurogenetics Neurological disorder Mice Mice Neurologic Mutants Central Nervous System Diseases medicine Animals Longitudinal Studies Physical Examination Gait Disorders Neurologic Sex Characteristics Behavior Animal General Neuroscience Body Weight Behavioral assessment Reproducibility of Results medicine.disease Disease Models Animal Phenotype SHIRPA Cohort Neurological dysfunction Female Psychology Single mutation Psychomotor Performance |
| Zdroj: | Neuroscience letters. 306(1-2) |
| ISSN: | 0304-3940 |
| Popis: | Mouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype and has been reported in a high throughput experiment in which different mutants were ascertained at one age point using stage 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurological dysfunction. The cohort aged from 1 to 16 months during this study and this is the first longitudinal SHIRPA analysis. |
| Databáze: | OpenAIRE |
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