Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age
| Autor: | K, Zaman, D A, Sack, M, Yunus, S E, Arifeen, G, Podder, T, Azim, S, Luby, R F, Breiman, K, Neuzil, S K, Datta, A, Delem, P V, Suryakiran, H L, Bock, S, Karim |
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| Rok vydání: | 2009 |
| Předmět: |
Diarrhea
Male Pediatrics medicine.medical_specialty Administration Oral Reoviridae Antibodies Viral medicine.disease_cause Placebo Drug Administration Schedule Rotavirus Infections Double-Blind Method Rotavirus medicine Humans Bangladesh General Veterinary General Immunology and Microbiology biology business.industry Poliovirus Rotavirus Vaccines Public Health Environmental and Occupational Health Infant medicine.disease biology.organism_classification Gastroenteritis Poliomyelitis Poliovirus Vaccines Vaccination Infectious Diseases Immunization Antibody Formation Immunology Molecular Medicine Enterovirus Female business |
| Zdroj: | Vaccine. 27:1333-1339 |
| ISSN: | 0264-410X |
| Popis: | Co-administration of oral live-attenuated human rotavirus vaccine RIX4414 (Rotarix) and oral polio vaccine (OPV) was assessed. Healthy infants were randomised to receive 2-doses of either: RIX4414 or placebo co-administered with OPV (12 and 16 weeks of age); or RIX4414 or placebo given 15 days after OPV. After vaccination, 56.5-66.7% of RIX4414 and 18.6% of placebo recipients had seroconverted for rotavirus IgA. No significant differences between RIX4414 groups with or without OPV co-administration were observed. No statistically significant differences were observed between groups for polio seroprotection rates. RIX4414 vaccine was immunogenic when co-administered with OPV and did not interfere with OPV seroprotection rates. |
| Databáze: | OpenAIRE |
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