Fascinating Chemopreventive Story of Wogonin: A Chance to Hit on the Head in Cancer Treatment
| Autor: | Rajesh Kumar, Della Grace Thomas Parambi, Akash Marathakam, Bijo Mathew, Siju Ellickal Narayanan, Jobin Jose, Seetha Harilal, Githa Elizabeth Mathew, Sahab Uddin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Telomerase
Chemosensitizer Apoptosis medicine.disease_cause 01 natural sciences Metastasis 03 medical and health sciences chemistry.chemical_compound Wogonin Cell Line Tumor Neoplasms Drug Discovery medicine Humans 030304 developmental biology Pharmacology 0303 health sciences biology business.industry Cancer Hydrogen Peroxide Cell cycle medicine.disease biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Flavanones Cancer research Scutellaria baicalensis Carcinogenesis business Drugs Chinese Herbal |
| Zdroj: | Current Pharmaceutical Design. 27:467-478 |
| ISSN: | 1381-6128 |
| Popis: | Cancer, global havoc, is a group of debilitating diseases that strikes family as well as society. Cancer cases are drastically increasing these days. Despite many therapies and surgical procedures available, cancer is still difficult to control due to limited effective therapies or targeted therapies. Natural products can produce lesser side effects to the normal cells, which are the major demerit of chemotherapies and radiation. Wogonin, a natural product extracted from the plant, Scutellaria baicalensis has been widely studied and found with a high caliber to tackle most of the cancers via several mechanisms that include intrinsic as well as extrinsic apoptosis signaling pathways, carcinogenesis diminution, telomerase activity inhibition, metastasis inhibition in the inflammatory microenvironment, anti-angiogenesis, cell growth inhibition and arrest of the cell cycle, increased generation of H2O2 and accumulation of Ca2+ and also as an adjuvant along with anticancer drugs. This article discusses the role of wogonin in various cancers, its synergism with various drugs, and the mechanism by which wogonin controls tumor growth. |
| Databáze: | OpenAIRE |
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