Elastographic ultrasound: an additional image tool in Sjögren's syndrome

Autor:	Luis Llorente, Eric Kimura-Hayama, Luis Azpeitia-Espinosa, Gabriela Hernández-Molina, Diego F. Hernández-Ramírez, Edgardo Reyes, Carlos Pacheco-Molina, Guadalupe Lima, Sergio Criales-Vera
Rok vydání:	2018
Předmět:	Adult Male medicine.medical_specialty Biopsy Submandibular Gland Gastroenterology Severity of Illness Index 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Rheumatology Fibrosis Predictive Value of Tests Major Salivary Gland Internal medicine medicine CXCL10 Humans Parotid Gland Serologic Tests CXCL13 Ultrasonography Doppler Color 030203 arthritis & rheumatology Salivary gland business.industry Ultrasound Middle Aged medicine.disease Chemokine CXCL10 medicine.anatomical_structure Cross-Sectional Studies Sjogren's Syndrome Case-Control Studies CCL28 Cytokines Elasticity Imaging Techniques Female business Rheumatism Biomarkers
Zdroj:	International journal of rheumatic diseases. 21(6)
ISSN:	1756-185X
Popis:	Aim To evaluate the stiffness of parotid and submandibular glands using elastography ultrasound and to correlate it with B-mode ultrasonographical, clinical and serological features, salivary profibrotic and inflammatory chemokines, and salivary gland fibrosis. Methods We performed B-mode and elastography ultrasound of major salivary glands of 26 patients with primary Sjogren's syndrome. We registered the shear wave velocity (SWV) and correlated it with the morphologic ultrasonographic changes assessed by the Hocevar scale. We assessed the European League Against Rheumatism (EULAR) Sjogren's Syndrome Disease Activity Index (ESSDAI), EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), non-stimulated whole salivary flow rate (NSWSF), C3 and C4 levels, anti-Ro/La antibodies, salivary inflammatory (C-X-C motif ligand 13 [CXCL13], CXCL10, CXCL8, C-C motif ligand 2 [CCL2], interleukin 10 [IL-10] and IL-6) and pro-fibrotic (CXCL14, CCL28, tumor necrosis factor-related apoptosis-inducing ligand and transforming growth factor β) chemokines and cytokines and evaluated the presence of fibrosis in the minor salivary gland. Results Ninety-two percent of patients were women; mean age was 51.1 ± 11 years; median disease duration was 6.1 years; 92.3% had oral symptoms and 26.9% fibrosis. The median B-mode score was 22.2 points and the median SWV 2.5 m/s (τ = 0.53, P = 0.001). The SWV correlated with the NSWSF (τ = -0.53, P = 0.001), ESSDAI (τ = 0.31, P = 0.03), glandular ESDDAI domain (τ = 0.36, P = 0.02), C4 levels (τ = -0.32, P = 0.04), salivary CXCL13 (τ = 0.29, P = 0.03) and CXCL10 (τ = 0.30, P = 0.003), but not with age and fibrosis. Conclusion WV correlated with the B-mode ultrasound score, systemic and glandular activity and in a large degree with CXCL10, an inflammatory chemokine, but not with fibrosis. An increased SWV might represent chronic glandular inflammation rather than fibrotic changes in these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cdb770e18314817ee550438d2a3584 https://pubmed.ncbi.nlm.nih.gov/29624878 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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