Genetic Variants of the PLCXD3 Gene are Associated with Risk of Metabolic Syndrome in the Emirati Population
| Autor: | Sami Alkayyali, Jalal Taneera, Mahmood Y. Hachim, Hind Hasswan, Hayat Aljaibeji, Nabil Sulaiman, Waseem El-Huneidi, Abdul Khader Mohammed |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty phosphatidylinositol-specific phospholipase C X domain HbA1c lcsh:QH426-470 Population 030209 endocrinology & metabolism Single-nucleotide polymorphism body mass index Type 2 diabetes minor allele frequency metabolic syndrome LDL 03 medical and health sciences BMI 0302 clinical medicine Internal medicine Genotype MetS Genetics medicine education SBP Genotyping triglycerides Genetics (clinical) education.field_of_study business.industry diastolic blood pressure single-nucleotide polymorphism medicine.disease MAF Minor allele frequency CJD lcsh:Genetics 030104 developmental biology Endocrinology Metabolic syndrome business Body mass index |
| Zdroj: | Genes Volume 11 Issue 6 Genes, Vol 11, Iss 665, p 665 (2020) |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes11060665 |
| Popis: | Phosphatidylinositol-specific phospholipase C X domain 3 (PLCXD3) has been shown to influence pancreatic &beta cell function by disrupting insulin signaling. Herein, we investigated two genetic variants in the PLCXD3 gene in relation to type 2 diabetes (T2D) or metabolic syndrome (MetS) in the Emirati population. In total, 556 adult Emirati individuals (306 T2D and 256 controls) were genotyped for two PLCXD3 variants (rs319013 and rs9292806) using TaqMan genotyping assays. The frequency distribution of minor homozygous CC genotype of rs9292806 and GG genotype of rs319013 were significantly higher in subjects with MetS compared to Non-MetS (p < 0.01). The minor homozygous rs9292806-CC and rs319013-GG genotypes were significantly associated with increased risk of MetS (adj. OR 2.92 95% CI 1.61&ndash 5.3 p < 0.001) (adj. OR 2.62 95% CI 1.42&ndash 4.83 p = 0.002), respectively. However, no associations were detected with T2D. In healthy participants, the homozygous minor genotypes of both rs9292806 and rs319013 were significantly higher fasting glucose (adj. p < 0.005), HbA1c (adj. p < 0.005) and lower HDL-cholesterol (adj. p < 0.05) levels. Data from T2D Knowledge Portal database disclosed a nominal association of rs319013 and rs9292806 with T2D and components of MetS. Bioinformatics prediction analysis showed a deleterious effect of rs9292806 on the regulatory regions of PLCXD3. In conclusion, this study identifies rs319013 and rs9292806 variants of PLCXD3 as additional risk factors for MetS in the Emirati population. |
| Databáze: | OpenAIRE |
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