Radiation Therapy After Breast-Conserving Surgery in Women 70 Years of Age and Older: How Wisely Do We Choose?
| Autor: | Tyler Wind, Alexandra S. Heerdt, Monica Morrow, Emily C. Zabor, Stephanie Downs-Canner, Armend Cobovic, Beryl McCormick |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Breast surgery Breast Neoplasms 030230 surgery Mastectomy Segmental Article 03 medical and health sciences 0302 clinical medicine Risk Factors Surgical oncology Statistical significance Internal medicine medicine Breast-conserving surgery Humans Neoplasm Invasiveness Prospective Studies Prospective cohort study Survival rate Aged Aged 80 and over business.industry Carcinoma Ductal Breast Prognosis Survival Rate Radiation therapy Carcinoma Lobular Receptors Estrogen 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant Surgery business Mastectomy Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology. 26:969-975 |
| ISSN: | 1534-4681 1068-9265 |
| Popis: | Despite data from randomized trials supporting omission of radiation therapy (RT) for women ≥ 70 years of age with T1, estrogen receptor-positive (ER+) tumors undergoing breast-conserving therapy (BCT), RT usage remains high. We reviewed our institutional experience to determine if risk factors for local recurrence or comorbidities influenced use. Women ≥ 70 years of age with T1, ER+, human epidermal growth factor receptor 2-negative (HER2−) tumors undergoing BCT in 2010–2012 were identified from a prospectively maintained database. Ten-year estimated mortality was calculated using the Suemoto index. The associations of clinicopathological features and mortality risk on receipt of RT were examined. Overall, 323 patients with 327 cancers were identified. Median age was 75 years, median tumor size was 1 cm, and all were clinically node negative; 53.7% of patients received RT. RT usage decreased with age (73.6%, age 70–74 years; 49.5%, age 75–79 years; 33.3%, age 80–84 years; 10.7%, ≥ 85 years; p |
| Databáze: | OpenAIRE |
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