In situ precipitated hydroxyapatite-chitosan composite loaded with ciprofloxacin: Formulation, mechanical, in vitro antibiotic uptake, release, and antibacterial properties

Autor: Hamid Ait Said, Hassan Noukrati, Hicham Ben youcef, Ismail Mahdi, Hassane Oudadesse, Allal Barroug
Přispěvatelé: Université Cadi Ayyad [Marrakech] (UCA), Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), OCP Foundation through a RandD Initiative 'Appel a projets autour des phosphates, APPHOS' [MAT-BAR-01/2017]
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Materials Chemistry and Physics
Materials Chemistry and Physics, 2023, 294, pp.127008. ⟨10.1016/j.matchemphys.2022.127008⟩
ISSN: 0254-0584
DOI: 10.1016/j.matchemphys.2022.127008⟩
Popis: International audience; Three-dimensional hydroxyapatite-chitosan (HA-CS) composites loaded with ciprofloxacin antibiotic (HA-CS-CIP) were formulated using the in situ and the solid-liquid method coupled with the freeze-drying process. The interaction of the HA-CS composite powder and ciprofloxacin antibiotic (CIP) was investigated by batch adsorption essays. The kinetic and the isotherm data were fitted well to the pseudo-second-order and Freundlich models, respectively. The compressive strength of the HA-CS composite was increased by 7-fold and 10-fold when using respectively 15 wt% and 30 wt% of the polymer compared to the HA-CS5 formulation (3.6 +/- 0.7 MPa) made only from HA powder and CS gel (5 wt%). However, this parameter decreased from 36.8 +/- 8.5 MPa down to 20.5 +/- 4.7 MPa when the antibiotic content increased from 0 up to 9 wt%, respectively. The in vitro release results showed a sustained and controlled CIP release for up to 10 days. The release data fitting and modeling indicate that the process follows a Fickian diffusion mechanism. Also, the formulated composite revealed an antibacterial effect against Staphylococcus aureus and Escherichia coli bacteria. The developed
Databáze: OpenAIRE
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