Stimuli-responsive weak polyelectrolyte multilayer films: A thin film platform for self triggered multi-drug delivery
| Autor: | Ashok M. Raichur, P. Gokul, S. Anandhakumar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Cell Survival Polymers Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Allylamine Biomaterials Electrolytes chemistry.chemical_compound Drug Delivery Systems Ciprofloxacin Chlorocebus aethiops Animals Thin film Vero Cells Transdermal chemistry.chemical_classification Bacteria Materials Engineering (formerly Metallurgy) Serum Albumin Bovine Polymer 021001 nanoscience & nanotechnology Polyelectrolyte Anti-Bacterial Agents 0104 chemical sciences Methacrylic acid chemistry Mechanics of Materials Ionic strength Drug delivery Cattle 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C. 58:622-628 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2015.08.039 |
| Popis: | Polyelectrolyte multilayer (PEM) thin film composed of weak polyelectrolytes was designed by layer-by-layer (LbL) assembly of poly(allylamine hydrochloride) (PAH) and poly(methacrylic acid) (PMA) for multi-drug delivery applications. Environmental stimuli such as pH and ionic strength showed significant influence in changing the film morphology from pore-free smooth structure to porous structure and favored triggered release of loaded molecules. The film was successfully loaded with bovine serum albumin (BSA) and ciprofloxacin hydrochloride (CH) by modulating the porous polymeric network of the film. Release studies showed that the amount of release could be easily controlled by changing the environmental conditions such as pH and ionic strength. Sustained release of loaded molecules was observed up to 8 h. The fabricated films were found to be biocompatible with epithelial cells during in-vitro cell culture studies. PEM film reported here not only has the potential to be used as self-responding thin film platform for transdermal drug delivery, but also has the potential for further development in antimicrobial or anti-inflammatory coatings on implants and drug-releasing coatings for stents. (C) 2015 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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