The role of alpha lipoic acid in female and male infertility: a systematic review
| Autor: | Valentina Bonanni, Chiara Di Tucci, Capri O, Renzo D'Amelio, Giulia Galati, Pierluigi Benedetti Panici, Giulia Mattei, Ludovico Muzii |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male endometriosis Infertility medicine.medical_specialty alpha lipoic acid infertility male factor polycystic ovary syndrome Endocrinology Diabetes and Metabolism Alpha-Lipoic Acid Endometriosis Embryonic Development 030209 endocrinology & metabolism medicine.disease_cause Male infertility Young Adult 03 medical and health sciences Oogenesis 0302 clinical medicine Endocrinology Semen Internal medicine medicine Humans Infertility Male chemistry.chemical_classification Reactive oxygen species 030219 obstetrics & reproductive medicine Male factor Thioctic Acid business.industry Health condition Obstetrics and Gynecology medicine.disease Oxidative Stress chemistry Female business Infertility Female Oxidative stress |
| Zdroj: | Gynecological Endocrinology. 37:497-505 |
| ISSN: | 1473-0766 0951-3590 |
| Popis: | Infertility is an increasingly frequent health condition, which may depend on female or male factors. Oxidative stress (OS), resulting from a disrupted balance between reactive oxygen species (ROS) and protective antioxidants, affects the reproductive lifespan of men and women. In this review, we examine if alpha lipoic acid (ALA), among the oral supplements currently in use, has an evidence-based beneficial role in the context of female and male infertility.We performed a search from English literature using PubMed database with the following keywords: 'female infertility', 'male infertility', 'semen', 'sperm', 'sub-fertile man', 'alpha-lipoic acid', ' alpha lipoic acid', 'lipoid acid', 'endometriosis', 'chronic pelvic pain', 'follicular fluid' and 'oocytes'. We included clinical trials, multicentric studies and reviews. The total number of references found after automatically and manually excluding duplicates was 180. After primary and secondary screening, 28 articles were selected.The available literature demonstrates the positive effects of ALA in multiple processes from oocyte maturation (0.87 ± 0.9% of oocyte in MII vs 0.81 ± 3.9%;ALA represents a promising new molecule in the field of couple infertility. More clinical studies are needed in order to enhance its use in clinical practice. |
| Databáze: | OpenAIRE |
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