ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas
| Autor: | Zhulin Yang, Li Xiong, Qiong Zou, Daiqiang Li, Ziru Liu, Yuan Yuan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adenosquamous carcinoma Cell Kaplan-Meier Estimate Adenocarcinoma CD13 Antigens medicine.disease_cause Gastroenterology Metastasis Carcinoma Adenosquamous 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine Biomarkers Tumor medicine Humans Gallbladder cancer Aconitate Hydratase business.industry Gallbladder Epithelial Cells Hematology General Medicine Middle Aged Prognosis medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Carcinoma Squamous Cell Immunohistochemistry Female Gallbladder Neoplasms Surgery business Carcinogenesis |
| Zdroj: | International Journal of Clinical Oncology. 25:1346-1355 |
| ISSN: | 1437-7772 1341-9625 |
| Popis: | Squamous cell/adenosquamous carcinoma (SC/ASC) is a rarely identified form of gallbladder cancer with poorly understood clinical features. As such, there is an urgent need to identify novel prognostic biomarkers for such gallbladder SC/ASC cases, and for gallbladder adenocarcinomas (ACs). The levels of ACO2 and ANPEP proteins were assessed via an EnVision-based immunohistochemical approach using 46 SC/ASC and 80 AC patient samples. There was a marked reduction in levels of ACO2 and ANPEP in gallbladder AC relative to normal adjacent tissue or benign gallbladder lesions. The was a significant correlation between lack of ACO2 and ANPEP and larger tumors, higher tumor-node-metastasis (TNM) staging, invasion, metastasis to regional lymph nodes, and ineligibility for surgical resection in both SC/ASC and AC tumor samples. Kaplan–Meier survival analyses further confirmed a relationship between ACO2 and ANPEP negativity and decreased overall survival in patients with these diseases (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink